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Paper | Regular issue | Vol 43, No. 1, 1996, pp.199-204
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7273
Ring Transformation of Fused Pyridazines. IV. Reaction of Halo-substituted Fused Pyridazines with Ynamines

Ken-ichi Iwamoto*, Sumiko Suzuki, Etsuo Oishi, Akira Miyashita, and Takeo Higashino

*School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422, Japan


Halo-substituted phthalazines reacted with two equivalents of ynamines to give penta-substituted pyridines through the N-N bond cleavage of pyridazine moiety. And it was proved that the N-N bond cleavage reaction of pyridazine ring is common to halo-substituted condensed pyridazines.