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Communication | Regular issue | Vol 43, No. 2, 1996, pp.263-266
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7267
Efficient Mononitration of Indolic Compounds with Nitric Acid Impregnated on Silica Gel

Nathalie Roué, Thierry Delahaigue, and Roland Barret*

*Université de Champagne-Ardenne, UFR de Pharmacie, Laboratoire d'Isolement, Transformation et Synthèse de Substances Naturelles, associé au CNRS, 51 rue Cognacq-Jay-F 51096 Reims Cedex, France


The methoxyindoles (N-benzenesulfonyl and 2-carbomethoxy) were mononitrated with nitric acid adsorbed on silica gel under mild conditions to give mononitroindoles in good chemical yields.