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Communication | Special issue | Vol 42, No. 2, 1996, pp.525-528
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7257
A Microwave-accelerated Intramolecular Diels-Alder Reaction. Approach to Compactin

Kazuhiko Takatori, Kazushi Hasegawa, Satoshi Narai, and Masahiro Kajiwara

*Department of Medicinal Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

Microwave irradiation drastically accelerated the intramolecular Diels-Alder reactions of 5a-c as compared with conventional heating. The resulting carboxylic acid (7c) was converted, to the decalin unit (2a), which is a possible key intermediate for synthesis of compactin (1).