Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 43, No. 1, 1996, pp.113-126
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7232
Asymmetric Synthesis of (+)- and (-)-Eptazocine via an Enzymatic Reaction

Shunsaku Shiotani*, Hirohiko Okada, Takako Yamamoto, Kumiko Nakamata, Jun Adachi, and Hiromasa Nakamoto

*Department of Chemistry, Faculty of Science, Toyama University, Gofuku 3190, Toyama 930, Japan


Starting from (R)-3-hydroxy-2-(p-methoxybenzyl)propyl acetate (R-(+)-4) prepared by enzymatic monoacetylation of 2-(p-methoxybenzyl)propane-1,3-diol (3) with lipase PS in the presence of vinyl acetate as an acetyl donor, lactones ((+)- and (-)-6) were obtained. Using the lactones, (+)- and (-)-eptazocine were synthesized.