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Paper | Regular issue | Vol 43, No. 1, 1996, pp.91-100
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7222
A Synthesis for Some New Thieno[2,3-b:4,5-b']dipyridines

Ma. Carmen Veiga, José Ma. Quintela,* and Carlos Peinador

*Departamento de Química Fundamental e Industrial, Facultad de Ciencias, Universidad de La Coruña, Campus de A Zapateira, E-15071, La Coruña, Spain

Abstract

An efficient method is proposed for the preparation of substituted thieno[2,3-b:4,5-b’]dipyridines (2a-h, 3a-g, and 5a-e), based on the Friedländer synthesis of 3-amino-5-cyano-7-ethoxy-2-formyl-4-phenylthieno[2,3-b]pyridine (1) with acyclic, cyclic, heterocyclic and α,β-unsaturated ketones. In addition, the reaction of 1 with guanidine sulfate yielded the fused triheterocyclic pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidine system (6).