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Paper | Regular issue | Vol 43, No. 1, 1996, pp.53-62
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7206
A Friedländer Approach to Polycondensed 1,8-Naphthyridine Derivatives

José Ma. Quintela,* Rosa Ma Arcas, Carmen Veiga, Carlos Peinador, Juan Vilar, and Vicente Ojea

*Departamento de Química Fundamental Industrial, Facultad de Ciencias, Universidad de La Coruña, Campus de A Zapateira, E-15071, La Coruña, Spain


An efficient method is proposed for the preparation of a variety of polycondensed 1,8-naphthyridines from 2-amino-3-cyano-6-ethoxy-5-formyl-4-phenylpyridine (1) by Friedländer condensation with cyclic and heterocyclic ketones.