Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 41, No. 9, 1995, pp.2043-2047
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7155
A Chemistry of Bisbenzylisoquinoline Alkaloid: Isomerization of Berbamine to Penduline in Methanol by Radical Reaction

Noriaki Kashiwaba, Shigeo Morooka, Michiko Kimura, Minoru Ono, Yoshie Murakoshi, Jun Toda, and Takehiro Sano

*Research Laboratories, Kaken Shoyaku Co., Ltd., 3-37-10, Shimorenjaku, Mitaka-shi, Tokyo 181, Japan

Abstract

Berbamine (1), a bisbenzylisoquinoline alkaloid, when treated with methanol, was isomerized to penduline (2), the C-1 epimer of 1. This isomerization was proved to proceed via a radical reaction by a free radical generated from methanol and molecular oxygen.