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Paper | Regular issue | Vol 41, No. 12, 1995, pp.2713-2728
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7141
Substituted Benzimidazoles. Part 1. Synthesis and Properties of Some 2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles

Mustafa M. El-Abadelah*, Salim S. Sabri, Musa H. Abu Zarga, and Raid J. Abdel-Jalil

*Chemistry Department , University of Jordan, Amman, Jordan


2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration < 100 μg/ml.