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Communication | Regular issue | Vol 41, No. 8, 1995, pp.1617-1620
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7110
An Efficient Synthesis of 4-Trifluoromethylated and 4-Perfluoroalkylated Imidazoles from Mesoionic 1,3-Oxazolium-5-olates

Masami Kawase, Setsuo Saito, and Teruo Kurihara

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama 350-02, Japan


4-Trifluoromethyl- and 4-perfluoroalkylimidazoles (4) were conveniently synthesized from mesoionic 4-trifluoroacetyl- or 4-perfluoroacyl-1,3-oxazolium-5-olate (1) via 2-imidazolines (3), which were formed through the regioselective attack of ammonia on the C(2) position of 1.