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Paper | Regular issue | Vol 41, No. 6, 1995, pp.1307-1318
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7064
Polycyclic N-Heterocyclic Compounds. 46. Synthesis of Thieno[2,3-h][1,6]naphthyridines from 2-(3-Cyanopropylthio)pyridine-3-carbonitrile

Kenji Sasaki, Abu Shara S. Rouf, Setsuo Kashino, and Takashi Hirota*

*Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan


An efficient methodology for the synthesis of thieno[2,3-h][1,6]naphthyridine skeleton via Smiles type rearrangement reaction followed by cyclization is described. Synthesis of its derivatives is also described.