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Paper | Regular issue | Vol 41, No. 5, 1995, pp.1001-1011
Published online, 1st January, 1970
DOI: 10.3987/COM-95-7035
Synthesis of Substituted 1,8-Naphthyridine Derivatives

José Ma Quintela,* Juan Vilar, Carlos Peinador, Carmen Veiga, and Vicente Ojea

*Departamento de Química Fundamental e Industrial, Facultad de Ciencias, Universidad de La Coruña, Campus de A Zapateira, E-15071 La Coruña, Spain


A variety of substituted 1,8-napthyridines were synthesized from 2-alkoxy-6-amino-3-cyano-5-formyl-4-phenylpyridine (1) by Friedländer condensation with aldehydes, aliphatic,cyclic or aromatic ketones and other active methylene compounds. Reactions of 1 with other compounds, were also studied.