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Communication | Special issue | Vol 40, No. 2, 1995, pp.539-542
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S82
Palladium-mediated Carbomacrolactonization of Terminal Hydroxyacetylenes and Its Utilization for a Synthesis of Exaltolide

Masaki Setoh, Osamu Yamada, and Kunio Ogasawara

*Pharnaceutical Institute, Tohoku University, Aramaki, Aoba-ku, sendai 980-8578, Japan


Carbomacrolactonization took place to give macrolactoneacetylenes when terminal hydroxyacetylenes were stirred under atmospheric pressure of carbon monoxide at room temperature in the presence of palladium(II) acetate and triethylamine. Using 15-pentadecyn-2-olide obtained, exaltolide was synthesized on catalytic hydrogenation.