HETEROCYCLES
An International Journal for Reviews and Communications in Heterocyclic ChemistryWeb Edition ISSN: 1881-0942
Published online by The Japan Institute of Heterocyclic Chemistry
Login / Registration
Registration
Registration for Editors, Referees
and Individual subscribers
Register for e-Alerts
New
| Brush Up | Your Heterocycles |
| ? |
Announcement
Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
No Publication Fee!
The publication of all articles is
Free of charge from January 1st 2020.
December 24, 2019
The publication of all articles is
Free of charge from January 1st 2020.
December 24, 2019
Announcement of Archives
Quick search
Advanced Search
Prepress & Curent Issues
Prepress
Current issues
- Vol. 106 Regular Issue
- Vol. 105 Special Issue
List of Issues
2023
- Vol. 106 Regular Issues
2022
- Vol. 105 Somsak Ruchirawat's Special Issues
- Vol. 104 Regular Issues
2021
- Vol. 103 Yasuyuki Kita's Special Issues
- Vol. 102 Regular Issues
2020
- Vol. 101 Kaoru Fuji's Special Issues
- Vol. 100 Regular Issues
2019
- Vol. 99 Tohru Fukuyama's Special Issues
- Vol. 98 Regular Issues
2018
- Vol. 97 Kiyoshi Tomioka's Special Issues
- Vol. 96 Regular Issues
2017
- Vol. 95 Professor Dr. Masakatsu Shibasaki's Special Issues
- Vol. 94 Regular Issues
2016
- Vol. 93 Professor Lutz F. Tietze's Special Issues
- Vol. 92 Regular Issues
2015
- Vol. 91 Regular Issues
- No. 12 pp. 2233 - 2454
- No. 11 pp. 2043 - 2232
- No. 10 pp. 1863 - 2042
- No. 9 pp. 1715 - 1862
- No. 8 pp. 1555 - 1714
- No. 7 pp. 1349 - 1554
- No. 6 pp. 1137 - 1348
- No. 5 pp. 931 - 1136
- No. 4 pp. 701 - 930
- No. 3 pp. 479 - 700
- No. 2 pp. 239 - 478
- No. 1 pp. 1 - 238
- Vol. 90 Professor Isao Kuwajima's Special Issues
2014
- Vol. 89 Regular Issues
- No. 12 pp. 2697 - 2932
- No. 11 pp. 2479 - 2696
- No. 10 pp. 2271 - 2478
- No. 9 pp. 2029 - 2270
- No. 8 pp. 1767 - 2028
- No. 7 pp. 1557 - 1766
- No. 6 pp. 1343 - 1556
- No. 5 pp. 1125 - 1342
- No. 4 pp. 845 - 1124
- No. 3 pp. 579 - 844
- No. 2 pp. 281 - 578
- No. 1 pp. 1 - 280
- Vol. 88 Professor Victor Snieckus's Special Issues
2013
2012
- Vol. 86 Prof. Dr. Ei-ichi Negishi's Special Issues
- Vol. 85 Regular Issues
- No. 12 pp. 2837 - 3150
- No. 11 pp. 2617 - 2836
- No. 10 pp. 2375 - 2616
- No. 9 pp. 2073 - 2374
- No. 8 pp. 1795 - 2072
- No. 7 pp. 1529 - 1794
- No. 6 pp. 1255 - 1528
- No. 5 pp. 993 - 1254
- No. 4 pp. 749 - 992
- No. 3 pp. 551 - 748
- No. 2 pp. 281 - 514
- No. 1 pp. 1 - 280
- Vol. 84 Dr. Albert Padwa's Special Issues
2011
- Vol. 83 Regular Issues
- No. 12 pp. 2689 - 2968
- No. 11 pp. 2451 - 2688
- No. 10 pp. 2223 - 2450
- No. 9 pp. 1953 - 2222
- No. 8 pp. 1727 - 1952
- No. 7 pp. 1435 - 1726
- No. 6 pp. 1187 - 1434
- No. 5 pp. 951 - 1186
- No. 4 pp. 695 - 950
- No. 3 pp. 447 - 694
- No. 2 pp. 247 - 446
- No. 1 pp. 1 - 246
- Vol. 82 Prof. Dr. Albert Eschenmoser's Special Issues
2010
- Vol. 82 Prof. Dr. Albert Eschenmoser's Special Issue
- Vol. 81 Regular Issues
- No. 12 pp. 2719 - 2978
- No. 11 pp. 2439 - 2718
- No. 10 pp. 2203 - 2438
- No. 9 pp. 1979 - 2202
- No. 8 pp. 1773 - 1978
- No. 7 pp. 1571 - 1772
- No. 6 pp. 1347 - 1570
- No. 5 pp. 1061 - 1346
- No. 4 pp. 795 - 1060
- No. 3 pp. 517 - 794
- No. 2 pp. 259 - 516
- No. 1 pp. 1 - 258
- Vol. 80 A. Suzuki's Special Issues
2009
- Vol. 79 J. Daly's Memorial Issue
- Vol. 78 Regular Issues
- No. 12 pp. 2919 - 3188
- No. 11 pp. 2661 - 2918
- No. 10 pp. 2431 - 2660
- No. 9 pp. 2193 - 2430
- No. 8 pp. 1917 - 2192
- No. 7 pp. 1627 - 1916
- No. 6 pp. 1387 - 1626
- No. 5 pp. 1109 - 1386
- No. 4 pp. 843 - 1108
- No. 3 pp. 555 - 842
- No. 2 pp. 281 - 554
- No. 1 pp. 1 - 180
- Vol. 77 K. Fukumoto's Special Issues
2008
- Vol. 76 Prof. Ryoji Noyori's Special Issues
- Vol. 75 Regular Issues
2007
- Vol. 74 Prof. Dr. Ekkehard Winterfeldt's Special Issue
- Vol. 73 Dr. Ivar Ugi's Memorial Issue
- Vol. 72 Prof. Kishi's Special Issue
- Vol. 71 Regular Issues
2006
- Vol. 70 Prof. Weinreb's Special Issue
- Vol. 69 Dr. Satoshi Omura's Special Issue
- Vol. 68 Regular Issues
- No. 12 pp. 2465 - 2766
- No. 11 pp. 2243 - 2464
- No. 10 pp. 2023 - 2242
- No. 9 pp. 1801 - 2022
- No. 8 pp. 1551 - 1800
- No. 7 pp. 1319 - 1550
- No. 6 pp. 1099 - 1318
- No. 5 pp. 879 - 1098
- No. 4 pp. 667 - 878
- No. 3 pp. 453 - 666
- No. 2 pp. 233 - 452
- No. 1 pp. 1 - 232
- Vol. 67 Prof. Trost's Special Issues
2005
- Vol. 66 Dr. Koga's Memorial Issue
- Vol. 65 Regular Issues
2004
- Vol. 64 Prof. Potier's Special Issue
- Vol. 63 Regular Issues
- No. 12 pp. 2707 - 3080
- No. 11 pp. 2457 - 2706
- No. 10 pp. 2199 - 2456
- No. 9 pp. 2005 - 2198
- No. 8 pp. 1757 - 2004
- No. 7 pp. 1531 - 1756
- No. 6 pp. 1267 - 1530
- No. 5 pp. 1009 - 1266
- No. 4 pp. 759 - 1008
- No. 3 pp. 505 - 758
- No. 2 pp. 241 - 504
- No. 1 pp. 1 - 240
- Vol. 62 Professor Paquette's Special Issue
2003
- Vol. 61 HETEROCYCLES 30th Anniversary Special Issue
- Vol. 60 Regular Issues
- No. 12 pp. 2621 - 2988
- No. 11 pp. 2417 - 2620
- No. 10 pp. 2211 - 2416
- No. 9 pp. 2017 - 2210
- No. 8 pp. 1779 - 2016
- No. 7 pp. 1561 - 1778
- No. 6 pp. 1303 - 1560
- No. 5 pp. 1045 - 1302
- No. 4 pp. 769 - 1044
- No. 3 pp. 519 - 768
- No. 2 pp. 289 - 518
- No. 1 pp. 1 - 288
- Vol. 59 Professor Kanaoka's Special Issues
2002
- Vol. 58 Professor Meyers' Special Issue
- Vol. 57 Regular Issues
- No. 12 pp. 2227 - 2500
- No. 11 pp. 1983 - 2226
- No. 10 pp. 1777 - 1982
- No. 9 pp. 1587 - 1776
- No. 8 pp. 1399 - 1586
- No. 7 pp. 1211 - 1398
- No. 6 pp. 1003 - 1210
- No. 5 pp. 781 - 1002
- No. 4 pp. 615 - 780
- No. 3 pp. 421 - 614
- No. 2 pp. 219 - 420
- No. 1 pp. 1 - 218
- Vol. 56 Professor Kutney's Special Issue
2001
- Vol. 55 Regular Issues
- No. 12 pp. 2251 - 2522
- No. 11 pp. 2043 - 2250
- No. 10 pp. 1839 - 2042
- No. 9 pp. 1635 - 1838
- No. 8 pp. 1433 - 1634
- No. 7 pp. 1231 - 1432
- No. 6 pp. 1015 - 1230
- No. 5 pp. 823 - 1014
- No. 4 pp. 623 - 822
- No. 3 pp. 435 - 622
- No. 2 pp. 223 - 434
- No. 1 pp. 1 - 222
- Vol. 54 Professor Ito's Special Issues
2000
- Vol. 53 Regular Issues
- No. 12 pp. 2601 - 2902
- No. 11 pp. 2353 - 2600
- No. 10 pp. 2119 - 2352
- No. 9 pp. 1877 - 2118
- No. 8 pp. 1669 - 1876
- No. 7 pp. 1471 - 1668
- No. 6 pp. 1239 - 1470
- No. 5 pp. 1011 - 1238
- No. 4 pp. 761 - 1010
- No. 3 pp. 519 - 760
- No. 2 pp. 261 - 518
- No. 1 pp. 1 - 260
- Vol. 52 Professor Mukaiyama's Special Issues
1999
- Vol. 51 Regular Issues
- No. 12 pp. 2801 - 3102
- No. 11 pp. 2553 - 2800
- No. 10 pp. 2301 - 2552
- No. 9 pp. 2029 - 2300
- No. 8 pp. 1775 - 2028
- No. 7 pp. 1499 - 1774
- No. 6 pp. 1225 - 1498
- No. 5 pp. 961 - 1224
- No. 4 pp. 721 - 960
- No. 3 pp. 471 - 720
- No. 2 pp. 231 - 470
- No. 1 pp. 1 - 230
- Vol. 50 HETEROCYCLES Vol. 50 Special Issues
1998
- Vol. 49 Dr. Witkop's Special Issue
- Vol. 48 Regular Issues
- No. 12 pp. 2473 - 2754
- No. 11 pp. 2221 - 2472
- No. 10 pp. 1985 - 2220
- No. 9 pp. 1739 - 1984
- No. 8 pp. 1513 - 1738
- No. 7 pp. 1307 - 1512
- No. 6 pp. 1103 - 1306
- No. 5 pp. 853 - 1102
- No. 4 pp. 617 - 852
- No. 3 pp. 421 - 616
- No. 2 pp. 215 - 420
- No. 1 pp. 1 - 214
- Vol. 47 Professor Nakanishi's Special Issues
1997
- Vol. 46 Dr. Yamada's Special Issue
- Vol. 45 Regular Issues
- No. 12 pp. 2299 - 2646
- No. 11 pp. 2089 - 2298
- No. 10 pp. 1869 - 2088
- No. 9 pp. 1647 - 1868
- No. 8 pp. 1433 - 1646
- No. 7 pp. 1247 - 1432
- No. 6 pp. 1047 - 1246
- No. 5 pp. 835 - 1046
- No. 4 pp. 643 - 834
- No. 3 pp. 435 - 642
- No. 2 pp. 231 - 434
- No. 1 pp. 1 - 230
- Vol. 44 Dr. Oae's Special Issue
1996
- Vol. 43 Regular Issues
- No. 12 pp. 2549 - 2896
- No. 11 pp. 2325 - 2548
- No. 10 pp. 2083 - 2324
- No. 9 pp. 1837 - 2082
- No. 8 pp. 1587 - 1836
- No. 7 pp. 1361 - 1586
- No. 6 pp. 1151 - 1360
- No. 5 pp. 937 - 1150
- No. 4 pp. 731 - 936
- No. 3 pp. 509 - 730
- No. 2 pp. 263 - 508
- No. 1 pp. 1 - 262
- Vol. 42 Professor Ban's Special Issues
1995
- Vol. 41 Regular Issues
- No. 12 pp. 2647 - 3014
- No. 11 pp. 2405 - 2646
- No. 10 pp. 2157 - 2404
- No. 9 pp. 1891 - 2156
- No. 8 pp. 1617 - 1890
- No. 7 pp. 1381 - 1616
- No. 6 pp. 1127 - 1380
- No. 5 pp. 877 - 1126
- No. 4 pp. 641 - 876
- No. 3 pp. 403 - 640
- No. 2 pp. 209 - 402
- No. 1 pp. 1 - 208
- Vol. 40 Professor Huisgen's Special Issues
1994
- Vol. 39 Dr. Brossi's Special Issues
- Vol. 38 Regular Issues
- No. 12 pp. 2581 - 2894
- No. 11 pp. 2377 - 2580
- No. 10 pp. 2147 - 2376
- No. 9 pp. 1957 - 2146
- No. 8 pp. 1707 - 1956
- No. 7 pp. 1449 - 1706
- No. 6 pp. 1205 - 1448
- No. 5 pp. 957 - 1204
- No. 4 pp. 709 - 956
- No. 3 pp. 477 - 708
- No. 2 pp. 235 - 476
- No. 1 pp. 1 - 234
- Vol. 37 Professor Katritzky's Special Issues
1993
- Vol. 36 Regular Issues
- No. 12 pp. 2657 - 2988
- No. 11 pp. 2437 - 2656
- No. 10 pp. 2185 - 2436
- No. 9 pp. 1941 - 2184
- No. 8 pp. 1715 - 1940
- No. 7 pp. 1455 - 1714
- No. 6 pp. 1195 - 1454
- No. 5 pp. 923 - 1194
- No. 4 pp. 651 - 922
- No. 3 pp. 421 - 650
- No. 2 pp. 219 - 420
- No. 1 pp. 1 - 218
- Vol. 35 Professor Taylor's Special Issues
1992
- Vol. 34 Regular Issues
- No. 12 pp. 2239 - 2526
- No. 11 pp. 2057 - 2238
- No. 10 pp. 1877 - 2056
- No. 9 pp. 1691 - 1876
- No. 8 pp. 1483 - 1690
- No. 7 pp. 1277 - 1482
- No. 6 pp. 1075 - 1276
- No. 5 pp. 875 - 1074
- No. 4 pp. 643 - 874
- No. 3 pp. 425 - 642
- No. 2 pp. 219 - 424
- No. 1 pp. 1 - 218
- Vol. 33 Dr. Hamana's Special Issues
1991
1990
- Vol. 31 Regular Issues
- No. 12 pp. 2091 - 2316
- No. 11 pp. 1903 - 2090
- No. 10 pp. 1733 - 1902
- No. 9 pp. 1565 - 1732
- No. 8 pp. 1393 - 1564
- No. 7 pp. 1183 - 1392
- No. 6 pp. 969 - 1182
- No. 5 pp. 783 - 968
- No. 4 pp. 577 - 782
- No. 3 pp. 397 - 576
- No. 2 pp. 191 - 396
- No. 1 pp. 1 - 190
- Vol. 30 Memorial Issues of Professor T. Kametani
1989
- Vol. 29 Regular Issues
- No. 12 pp. 2245 - 2448
- No. 11 pp. 2051 - 2244
- No. 10 pp. 1857 - 2050
- No. 9 pp. 1649 - 1856
- No. 8 pp. 1435 - 1648
- No. 7 pp. 1221 - 1434
- No. 6 pp. 997 - 1220
- No. 5 pp. 841 - 996
- No. 4 pp. 629 - 840
- No. 3 pp. 411 - 628
- No. 2 pp. 205 - 410
- No. 1 pp. 1 - 204
- Vol. 28 Professor D. H. R. Barton's Special Issues
1988
1987
- Vol. 26 Regular Issues
- No. 12 pp. 3051 - 3402
- No. 11 pp. 2801 - 3050
- No. 10 pp. 2573 - 2800
- No. 9 pp. 2323 - 2572
- No. 8 pp. 2025 - 2322
- No. 7 pp. 1727 - 2024
- No. 6 pp. 1439 - 1726
- No. 5 pp. 1161 - 1438
- No. 4 pp. 863 - 1160
- No. 3 pp. 585 - 862
- No. 2 pp. 313 - 584
- No. 1 pp. 1 - 312
- Vol. 25 Professor G. Stork's Special Issue
1986
1985
1984
- Vol. 22 Regular Issues
- No. 12 pp. 2703 - 2960
- No. 11 pp. 2429 - 2702
- No. 10 pp. 2183 - 2428
- No. 9 pp. 1943 - 2182
- No. 8 pp. 1667 - 1942
- No. 7 pp. 1473 - 1666
- No. 6 pp. 1303 - 1472
- No. 5 pp. 981 - 1302
- No. 4 pp. 657 - 980
- No. 3 pp. 449 - 656
- No. 2 pp. 223 - 448
- No. 1 pp. 1 - 222
- Vol. 21 Special Issues of the 19th International Congress of Heterocyclic Chemistry
1983
1982
- Vol. 19 Regular Issues
- No. 12 pp. 2247 - 2434
- No. 11 pp. 2011 - 2246
- No. 10 pp. 1793 - 2010
- No. 9 pp. 1565 - 1792
- No. 8 pp. 1367 - 1564
- No. 7 pp. 1191 - 1366
- No. 6 pp. 1003 - 1190
- No. 5 pp. 815 - 1002
- No. 4 pp. 633 - 814
- No. 3 pp. 465 - 632
- No. 2 pp. 205 - 464
- No. 1 pp. 1 - 204
- Vol. 18 Professor H. C. Brown's Special Issue
- Vol. 17 Professor K. Tsuda's Special Issue
1981
- Vol. 16 Regular Issues
- No. 12 pp. 2085 - 2310
- No. 11 pp. 1855 - 2084
- No. 10 pp. 1647 - 1854
- No. 9 pp. 1441 - 1646
- No. 8 pp. 1271 - 1440
- No. 7 pp. 1077 - 1270
- No. 6 pp. 881 - 1076
- No. 5 pp. 699 - 880
- No. 4 pp. 521 - 698
- No. 3 pp. 343 - 520
- No. 2 pp. 195 - 342
- No. 1 pp. 1 - 194
- Vol. 15 Professor T. Kametani's Special Issues
1980
1979
- Vol. 13 Professor H. Umezawa's Special Issue
- Vol. 12 Regular Issues
1978
- Vol. 11 Professor T. Nozoe's Special Issue1978
- Vol. 10 Professor A. Butenandt's Special Issue
- Vol. 9 Regular Issues
1977
- Vol. 8 Professor S. Sugasawa's Special Issue
- Vol. 7 Professor R. B. Woodward's Special Issues
- Vol. 6 Regular Issues
1976
- Vol. 5 Dr. K. Takeda's Special Issue
- Vol. 4 Regular Issues
1975
1974
1973
- Vol. 1 Regular Issues
Online article for Non-subscribers
Pay per view
Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com
Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.
Paper | Special issue | Vol 40, No. 1, 1995, pp.425-440
Published online, 1st January, 1970■ Purification and Characterization of a Cytochrome P450 Enzyme from Pig Liver, Catalyzing the Phenol Oxidative Coupling of (R)-Reticuline to Salutaridine, the Critical Step in Morphine Biosynthesis
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S73
■ Purification and Characterization of a Cytochrome P450 Enzyme from Pig Liver, Catalyzing the Phenol Oxidative Coupling of (R)-Reticuline to Salutaridine, the Critical Step in Morphine Biosynthesis
Tobias Amann, Peter H. Ross, Hoon Huh, and Meihart H. Zenk
*Lefrstuhl für Pharmazeutische Biologie, Universität München, Karlstr. 29, 80333 München, Germany
Abstract
The cytochrome P450 enzyme catalyzing the conversion of (R)-reticuline to salutaridine in the presence of cytochrome c reductase, NADPH and O2 was purified to homogeneity from pig liver and shown to be a highly regio- and stereoselective enzyme. This finding supports the view that the occurrence of morphine in mammals is of endogenous and not of dietary origin.
The Japan Institute of Heterocyclic Chemistry Publications is a partner of :
Copyright ⓒ 2023 The Japan Institute of Heterocyclic Chemistry