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Paper | Special issue | Vol 42, No. 1, 1996, pp.213-218
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S6-1
A Convenient Route to the Imidazo[4,5-b]pyridines

Kenichi Harada, Tominari Choshi, Eiichi Sugino, Koichi Sato, and Satoshi Hibino

*Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-02, Japan


The reaction of the acroleins possessing a leaving group, derived from alkenyl sulfides by Vilsmeier reaction, with 4-amino-1-methylimidazole provided a new and convenient route to the imidazo[4,5-b]pyridines, the reaction mechanisms of which were examined by a deuterium labelled experiment.