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Paper | Special issue | Vol 40, No. 2, 1995, pp.653-660
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S52
An Aproach to the Synthesis of a Papaverine Analogue Containing a Quinazoline Ring System

Akira Miyashita, Hideaki Matsuda, Yoshiyuki Matsuoka, Ken-ichi Iwamoto, and Takeo Higashino

*Schol of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan


Synthesis of a papaverine analogue containing a quinazoline ring system (4-azapapaverine) was achieved. In the synthesis of 4-azapapaverine catalytic aroylation is a useful reaction. Preparation of several 4-aroyl-6,7-dimethoxyquinazolines was accomplished by aroylation.