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Paper | Special issue | Vol 42, No. 1, 1996, pp.195-211
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S5-1
A Synthesis of the Derivatives of 1,2,3,5,10,10a-Hexahydrobenz[f]indolizine-6,9-dione Having Antifungal Activity as a Simple Model of SaframycinA

Akinori Kubo, Tatsuya Nakai, Yuichi Koizumi, Yoshiyasu Kitahara, Naoki Saito, Yuzuru Mikami, Katsukiyo Yazawa, and Jun Uno

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


A simple and efficient synthesis of 1,2,3,5,10,10a-hexahydrobenz[f] indolizine-6,9-dione (7) and its analogs (28-30) is described starting from the corresponding lactam (15b).