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Communication | Special issue | Vol 40, No. 2, 1995, pp.501-506
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S45
Isolation and Structure of the Human Cancer Cell Growth Inhibitory Phakellistatin 4 from the Western Pacific Sponge Phakellia Costata

George R. Pettit, Jun-ping Xu, Zbigniew Cichacz, Jean M. Schmidt, Ann-Christine Dorsaz, Michael R. Boyd, and Ronald L. Cerny

*Cancer Research Institute, Department of Chemistry and Biochemistry, Arizona State University, Main Campus, P.O. Box 872404, Tempe, AZ 85287-1604, U.S.A.


Structural elucidation by high field 2D nmr and FAB-ms/ms techniques led to cyclo-(Pro-Thr-Pro-Phe-Ile-Phe-Ser) as the assignment for phakellistatin(4) a new cell growth inhibitory peptide from the Chuuk Archipelago marine sponge Phakellia costata.