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■ Biorational Design of Herbicides: Synthesis of Inhibitors of the PFP Enzyme

Mukund S. Chorghade* and Csaba T. Cseke

*Abbott Laboratories, Abbott Park, N. Chicago, IL60064, U.S.A.

Abstract

Transition state and reaction coordinate analog inhibitors of the PFP enzyme were synthesized for the biorational design of herbicides. Some of the promising ones were scaled up and tested on whole plants. Open chain, aza and phosphonated analogs of fructose showed significant PFP inhibitory activity.