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■ Phenolic Compounds in Erythrina x bidwilli and Their Activity Against Oral Microbial Organisms

Munekazu Iinuma,* Yasutoshi Okawa, Toshiyuki Tanaka, Yasuko Kobayashi, and Ken-ichi Miyauchi

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan

Abstract

The bioassay-directed fractionation of an acetone extract of the root bark of Erythrina x bidwillii which shows a significant antibacterial activity against oral bacteria led to isolate three new phenolic compounds (bidwillols A and B, and bidwillon C) and a known pterocarpene (erycristagallin), the structures of which were characterized by spectral and physical properties. Among them, erycristagallin showed potent microbial activity against Streptococcus mutans, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans.