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Paper | Special issue | Vol 39, No. 2, 1994, pp.571-579
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S(B)48
Conformational States of Indolactams. Structures of 13-N-Desmethylidolactam-V and 13-O-Indolactam-V

Yasuyuki Endo,* Takashi Imada, Kentaro Yamaguchi, and Koichi Shudo

*Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan


Tumor-promoting teleocidins are known to exist in an equilibrium between two conformational states, the twist and the sofa form, in solution. 13-O-Indolactam-V, takes the fold form in solution and in the crystal, indicating that the conformation of the nine-membered lactam ring of indolactams is influenced by the nature of the group at position 13.