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Communication | Special issue | Vol 39, No. 2, 1994, pp.435-438
Published online, 1st January, 1970
DOI: 10.3987/COM-94-S(B)31
Guanidinium Carboxylates: Preparation of 3-Carboxyoctahydro-9aH-pyrimidin-9a-ylium Chloride

Anne-Laure Grillot and David. J. Hart*

*Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, U.S.A.

Abstract

The title guanidinium carboxylate (2) was prepared from tert-butyl 2-bromomethylacrylate (3) using an 11-reaction sequence in 12% overall yield. Sequential addition of two differentiated amino groups to the starting acrylate played a key role in the synthesis.