Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 41, No. 6, 1995, pp.1181-1196
Published online, 1st January, 1970
DOI: 10.3987/COM-94-7005
Synthesis of Designed Functional Models of Bleomycin Incorporating Imidazole - containing Lexitropsins as Novel DNA Recognition Sites

Liren Huang and J. William Lown*

*Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2 Canada

Abstract

Synthesis and characterization of compounds 1a - d, designed functional models for the antitumor antibiotic bleomycin, in which AMPHIS serves as the metal complexing subunit, chiral 1,2-trans-disubstituted cyclopropane as linkers and imidazole-containing lexitropsins as DNA sequence selective binding sites, are described.