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Paper | Regular issue | Vol 41, No. 6, 1995, pp.1181-1196
Published online, 1st January, 1970
DOI: 10.3987/COM-94-7005
Synthesis of Designed Functional Models of Bleomycin Incorporating Imidazole - containing Lexitropsins as Novel DNA Recognition Sites

Liren Huang and J. William Lown*

*Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2 Canada


Synthesis and characterization of compounds 1a - d, designed functional models for the antitumor antibiotic bleomycin, in which AMPHIS serves as the metal complexing subunit, chiral 1,2-trans-disubstituted cyclopropane as linkers and imidazole-containing lexitropsins as DNA sequence selective binding sites, are described.