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Paper | Regular issue | Vol 41, No. 5, 1995, pp.937-945
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6981
Synthesis and Antiviral Evaluation of Furopyrimidine Diones Cyclic and Acyclic, Nucleoside Analogues

Jacques Renault, Fabrice Jourdan, Daniel Ladurée*, and Max Robba

*Centre d'Etudes et de Recherche sur le Médicament de Normandie, U. F. R. des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032 Caen, France

Abstract

Following Vorbrüggen and Niedballa’s method1, we have carried out the synthesis of new cyclic and acyclic nucleoside analogues, whose aglycone was the furopyrimidinedione (3). Among the various compounds that we obtained was the β-D-ribonucleoside (8) which gave us access to the β-D-arabinonucleoside (11) whose synthesis by Vorbüggen and Niedballa’s method1 had remained unsuccessful. All the new compounds were tested against human immunodeficiency virus 1 (HIV-1). None of these compounds showed significant activity.