Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 41, No. 3, 1995, pp.409-414
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6971
On the Chemistry of the 18-Deoxycytochalasin H, HIV-1 Protease Inhibitor, L-696,474. 2: Novel Ring Annulations

B. Moon Kim*, James P. Guare, and Steven M. Pitzenberger

*Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, U.S.A.


Unprecedented annulation of the 11-membered ring portion of 18-deoxycytochalasin H, a 3μM inhibitor of HIV-1 protease, has been observed furnishing a novel tetracyclic cytochalasin (5). Subsequent desilylation of 5 provided yet another set of new tetracyclic cytochalasin derivatives.