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Communication | Regular issue | Vol 41, No. 3, 1995, pp.403-408
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6970
On the Chemistry of the 18-Deoxycytochalasin H, HIV-1 Protease Inhibitor, L-696,474. 1: Degradation Studies Leading to the 2-Isoindolone Core

B. Moon Kim* and James P. Guare

*Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, U.S.A.


Degradation studies of 18-deoxycytochalasin H, a 3 μM HIV-1 protease inhibitor, led to a 2-isoindolone core with conservation of functional groups on the bicyclic ring.