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Communication | Regular issue | Vol 41, No. 2, 1995, pp.245-248
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6965
A Synthesis of Optically Active Platyphyllide. Determination of Its Absolute Configuration

Shigeru Nagashima, Hitomi Ontsuka, Motoo Shiro, and Ken Kanematsu*

*Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University 62, Higashi-ku, Fukuoka 812, Japan


The first enantioselective total synthesis of platyphyllide (1), based on the allenyl ether intramolecular cycloaddition strategy, is described, revealing the absolute configuration of this compound.