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Communication | Regular issue | Vol 41, No. 2, 1995, pp.215-218
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6926
Regiospecific Synthesis of N-Alkyl-4- and 5-Substituted Imidazoles

Gideon Shapiro* and Berta Gomez-Lor

*Preclinical Research, Sandoz Pharma Ltd., CH-4002 Basel, Switzerland


A facile regiospecific synthesis of 4- and 5-substituted N-alkyl imidazoles has been developed from N-trimethylsilyloxyethylimidazole(s). The method combines directed metallation with alkyl triflate mediated imidazole quaternization and SEM group cleavage.