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Paper | Regular issue | Vol 38, No. 11, 1994, pp.2455-2462
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6872
A New Synthetic Route to Functionalized 2-Azabicyclo[2.2.2]octane

Morio Asaoka,* Naoto Ohkura, Masaru Yokota, Syuzo Sonoda, and Hisashi Takei

*Department of Life Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Instituteof Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan

Abstract

Functionalized 2-azabicyclo[2.2.2]octane ring system was prepared via intramolecular SN2 ring opening of epoxide by an amide anion.