Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 38, No. 10, 1994, pp.2289-2293
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6839
5H-[1,2,4]Oxadiazolo[5,4-d][1,5]benzothiazepines: Synthesis and Stereochemistry

Alba Chimirri,* Rosaria Gitto, Silvana Grasso, Pietro Monforte, and Maria Zappalà

*Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy


The functionalization of the thiazepine system by 1,3-dipolar cycloaddition of benzonitriloxide to the C=N double bond of 1,5-benzothiazepine derivatives, is described. The configurational and conformational properties of the 3a,4-dihydro-1-phenyl-5H-[1,2,4]oxadiazolo[5,4-d][1,5]benzothiazepines have been determined by nmr spectroscopy assisted by NOE measurements.