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Paper | Regular issue | Vol 41, No. 2, 1995, pp.259-265
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6831
Synthesis of 6-Fluoroquinolones Substituted at C-7 by 1'-Demethyllincomycin and by Dihydroconessimine

Sandrine Deloisy, Alain Olesker*, and Gabor Lukacs

*Institut de Chimie des Substances Naturelles, C.N.R.S., 91198 Gif sur Yvette, France

Abstract

The boron-chelated carboxylic acid of 6,7-difluoroquinolone (8) was substituted at C-7 by the 2,3,4,7-tetra-O-acetate of 1’-demethyllincomycin (4) and by dihydroconessimine (14). The resulting dechelated products did not reveal any antibacterial activity. A new efficient procedure for the preparation of the 2,3,4,7-tetra-O-acetate of 1’-demethyllincomycin (4) is proposed.