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Paper | Regular issue | Vol 38, No. 10, 1994, pp.2243-2246
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6822
Improved Process for the Preparation of 2-Methyl-3-trifluoromethylaniline: A Versatile Intermediate for Flunixin Synthesis

Rabih Jaouhari* and Philip Quinn

*QUCHEM, Custom Synthesis and Process Development Research Centre, School of Chemistry, The Quee‘s University of Belfast, David Keir Kuilding, Belfast, BT9 5AG, U.K.

Abstract

A detailed new experimental investigation into the synthesis of Flunixin via 2-methyl-3-trifluoromethylaniline is described. The coupling process between 2-methyl-3-trifluoromethylaniline and 2-chloronicotinate was achieved stoichiometrically and in high yield, when ethylene glycol was used as reaction solvent at 160 °C.