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Paper | Regular issue | Vol 38, No. 9, 1994, pp.2091-2097
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6818
An Efficient Synthesis of Di- and Trimethoxy-4-quinolones

Jun Toda, Takako Fuse, Etsuko Kishikawa, Naoko Ando, Rumi Negishi, Yoshie Horiguchi, and Takehiro Sano*

*Showa Pharmaceutical University, 3-3165, Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan


An excellent method of preparation of N-aryl-enamino esters (4) was achieved by developing N-N exchange of an N-methyl-enamino ester (6) with di- and trimethoxyanilines (3). Thermolysis of 4 in xylene gave di- and trimethoxy-4-quinolones (7) in excellent yields.