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Paper | Regular issue | Vol 38, No. 9, 1994, pp.2073-2079
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6805
Synthesis of Novel 4-Arylamino-2-dialkylaminoquinazolines under High Pressure

Akihiro Oishi,* Masahiko Yasumoto,* Midori Goto, Tohru Tsuchiya, Isao Shibuya, and Yoichi Taguchi

*National Institute of Materials and Chemical Research, 1-1, Higashi, Tsukuba, Ibaraki 305, Japan


Novel 4-arylamino-2-dialkylaminoquinazolines (salt) were obtained in good yields by reaction of dialkylcyanamides with 4-substituted phenyl isothiocyanates at 800 MPa. The molecular structure of 6-chloro-4-(4‘-chlorophenylamino)-2-dimethylaminoquinazoline 2"-chlorobenzoate (3e) was determined by X-ray crystallographic analysis.