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Communication | Regular issue | Vol 38, No. 6, 1994, pp.1221-1224
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6712
Bifunctional Antitumor Agents: Pyrrolo[9,10]phenanthrenes as Intercalative Drug Delivery Vehicles

Graham B. Jones,* Jude E. Mathews, and W. Kenneth Banner

*Howard L. Hunter Laboratories, Department of Chemistry, Clemson University, Clemson, SC 29634-1905, U.S.A.

Abstract

The preparation of a pyrrolo[9,10]phenanthrene nucleus is described. The utility of the template as a potential DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis chloroethylamine alkylating system.