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Paper | Regular issue | Vol 38, No. 6, 1994, pp.1407-1412
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6711
Aminolysis of N-Acylpyrazoles

Choji Kashima,* Iwao Fukuchi, Katsumi Takahashi, and Akira Hosomi*

*Department of Chemistry, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba-shi, Ibaraki, 305-8571, Japan

Abstract

1-Acylpyrazoles reacted with amines having a tiny substituent to afford the corresponding amides. The aminolysis with bulky amines was controlled to be retarded by the steric factors. Due to this steric interaction, the stereoselective aminolysis was observed. This selectivity of aminolysis should increase the utility of pyrazoles as auxiliary compounds in the synthetic loop.