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Paper | Regular issue | Vol 38, No. 6, 1994, pp.1361-1365
Published online, 1st January, 1970
DOI: 10.3987/COM-94-6695
Synthesis of 2-Bnzamidoisoquinoline-1(2H)-one from 2-Vinylbenzoic Acid

Partha S. Ray* and Michael J. Manning

*Agricultural Chemical Group, FMC Corporation, P.O. Box 8, Princeton, New Jersey 08543, U.S.A.


Treatment of N1-(2-vinylbenzoyl)-N2-benzoylhydrazine (2) with 3-chloroperoxybenzoic acid let to a cyclization of the intermediate epoxy derivative (3a) to give the alcohol (4a). Conversion of 4a to the thiocarbonate (5a) followed by a Chugaev type reaction gave the title compound (6).