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Paper | Special issue | Vol 37, No. 3, 1994, pp.1521-1527
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S77
A Facile Synthesis of Mercaptopyrazolidine Useful for Construction of the Pendant Moiety of 1β-Methylcarbapenem L-627

Toshio Kumagai, Satoshi Tamai, Takao Abe, Yunosuke Nagase, Yoshinori Inoue, and Yoshimitsu Nagao*

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan

Abstract

A 4-mercaptopyrazolidine derivative (3), which is a synthetic intermediate of the pendant moiety of 1β-methylcarbapenem L-627 (2), was synthesized by a practical method starting from hydrazine hydrate.