Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 37, No. 3, 1994, pp.1447-1450
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S71
A Short Synthesis of a Conformationally Restricted Analog of the Neurotransmitter Serotonin with Reduced Basicity

John E. Macor* and Kevin Ryan

*Department of Medical Chemistry, Central Research Division, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, U.S.A.


The synthesis of a less basic, conformationally restricted analog of serotonin is described [2-(5-methoxyindol-3-ylmethyl)imidazole (1)]. The crucial carbon-carbon bond formation step in this synthesis involves the attack of a 2-lithioimidazole anion on an indole-3-carboxaldehyde derivative.