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Communication | Special issue | Vol 37, No. 1, 1994, pp.275-282
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S59
Transition-Metal Binding Site of Bleomycin. Significance of the β-Aminoalaninamide Appendage in Regulating Oxygen Activation

Toru Sugiyama, Masaji Ohno, Masakatsu Shibasaki, Masami Otsuka,* Yukio Sugiura, Susumu Kobayashi, and Kenji Maeda

*Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan

Abstract

A synthetic model study on the iron-binding site of bleomycin demonstrated that the dioxygen-activating properties of ligands largely depend on the characteristics of functional groups contained in the β-aminoalaninamide moiety.