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Communication | Special issue | Vol 37, No. 2, 1994, pp.667-671
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S42
Reaction of Pyrylium Salts with Amino Acid Derivatives Part 3. Ribonuclease A Inactivation by Trisubstituted Pyrylium Salts

Claudiu T. Supuran, Emil Pop, and Antonie Dinculescu*

*Pharmos Corporation, 2 Innovation Drive, Alachua, FL32615, U.S.A.

Abstract

Treatment of ribonuclease A with 2,4,6-trisubstituted pyrylium salts completely inhibits the activity of this enzyme. The inactivation is probably due to the reaction of the ε-amino group of the active site Lys 41 residue with the pyrylium cation, leading to pyridinium derivatives which hinder the access of substrates to the active site of the enzyme