Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 37, No. 2, 1994, pp.667-671
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S42
Reaction of Pyrylium Salts with Amino Acid Derivatives Part 3. Ribonuclease A Inactivation by Trisubstituted Pyrylium Salts

Claudiu T. Supuran, Emil Pop, and Antonie Dinculescu*

*Pharmos Corporation, 2 Innovation Drive, Alachua, FL32615, U.S.A.


Treatment of ribonuclease A with 2,4,6-trisubstituted pyrylium salts completely inhibits the activity of this enzyme. The inactivation is probably due to the reaction of the ε-amino group of the active site Lys 41 residue with the pyrylium cation, leading to pyridinium derivatives which hinder the access of substrates to the active site of the enzyme