Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 37, No. 1, 1994, pp.235-238
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S40
Synthesis of the Novel Tricyclic Heterocycle, 1H-1,4,7-Triazaphenalene, Pyridine-containing Ring System: Hexamethyl 1H-1,4,7-Triazaphenalene-2,3,5,6,8,9-hexacarboxylate

Yoshinori Tominaga* and Kenichi Nomoto

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

The reaction of 3-amino-3-methylthio-2-cyanoacrylonitrile (1) with excess dimethyl acetylenedicarboxylate(DMAD) in the presence of potassium carbonate in dimethyl sulfoxide gave a novel tricyclic heterocycle, hexamethyl IH-1,4,7-triazaphenalene-2,3,5,6,8,9-hexacarboxylate (5). When one equivalent of DMAD was used in this reaction, dimethyl 4-amino-3-cyano-2-methylthiopyridine-5,6-dicarboxylate(3), a key intermediate of 5, was obtained.