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Communication | Special issue | Vol 37, No. 1, 1994, pp.227-233
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S36
Structure and Spectral Properties of β-Carbolines, Part 6. Regiooooselectivity of Cyclocondensation of Spiro[piperidine-m',1-(1,2,3,4-tetrahydro-β-carbolines)] with Aldehydes

Maria J. Mokrosz,* Maria H. Paluchowska, Stanislaw Misztal, and Jerzy L. Mokrosz

*Department of Mmedical Chemistry, Institute of Pharmacology, Polish Acadeamy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland

Abstract

Cyclocondensation of spiro derivatives of 1,2,3,4-tetrahydro-β-carbolines (1) and (5) with aldehydes was found to be a regioselective process. The structure of individual new ring systems. i.e. N-3,7 (2-4), N-2,7 (6) and N-2,14 (7-9) cyclocondensation products, was determined using 1H nmr techniques.