Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 37, No. 1, 1994, pp.387-400
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S20
Synthesis of Hybrid Tilivallines and Their 11-Cyano Analogs

Nobuyuki Matsunaga, Toyohiko Aoyama, and Takayuki Shioiri*

*Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan


Hybrid tilivallines (4), derived from tilivalline (1a) and anthramycin (2) or tomaymycin (3), and their 11-cyano analogs (15) have been efficiently synthesized from the acetal amides (7a, b) : the key step is an intramolecular Mannich type cyclization accompanied with introduction of indole or nitrile function.