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Paper | Special issue | Vol 37, No. 3, 1994, pp.1615-1622
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S127
Synthesis and Flash Vacuum Pyrolysis of Isoxazolo- and Isothiazolo[5,4-d]pyrimidines

C. Oliver Kappe, Robert Flammang, and Curt Wentrup*

*Department of Chemistry, The University of Queensland, Brisbane, Qld 4072, Australia


The multi-step synthesis of isothiazolo[5,4-d]pyrimidines (1c,d) and isoxazolo[5,4-d]pyrimidine (1b) is described. Flash vacuum pyrolysis of 1b leads to phenyliminopropadienone, Ph-N=C=C=C=O, which was identified by Ar matrix infrared spectroscopy.