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Communication | Special issue | Vol 37, No. 1, 1994, pp.157-162
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S12
A Convenient Synthetic Method for Fluorine-containing Naphtho[1,2-d][1,3]thiazines from N, N-Dialkyl-2,4-bis(trifluoroacetyl)-1-naphthylamines

Etsuji Okada, Ryoichi Masuda,* Masaru Hojo, Hiroshi Tone, and Takeshi Tomifuji

*Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan


The reaction of N,N-dialkyl-2,4-bis(trifluoroacetyl)-1-naphthylamines with Lawesson’s reagent proceeded in refluxing toluene to give fluorine-containing naphtho[1,2-d][1,3]thiazines in satisfactory yields. The regioselectivity in this cyclization was also investigated.