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Communication | Special issue | Vol 37, No. 1, 1994, pp.153-156
Published online, 1st January, 1970
DOI: 10.3987/COM-93-S11
Convenient Synthetic Methods for 5-Trifluoromethyloxazoles and 5-Trifluoromethylthiazoles

Yasuhiro Kamitori, Masaru Hojo, Ryoichi Masuda,* Masaaki Wada, and Toshiya Takahashi

*Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan

Abstract

5-(Trifluoromethyl)oxazoles (3) and 5-(trifluoromethyl)thiazoles (4) were conveniently as well as effectively synthesized from 3-(N-tert-butyl-N-methylhydrazono)-1,1,1-trifluoroalkan-2-ones (1) via 5-(trifiuoromethyl)-3-oxazoline (2). One-pot conversion of 1 to 4 also proceeded successfully.