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Paper | Regular issue | Vol 38, No. 1, 1994, pp.71-80
Published online, 1st January, 1970
DOI: 10.3987/COM-93-9462
A Synthesis of Pyrano[2,3-c]pyrroles from Cinnamoyloximinoacetonitrile

Galal A. M. Nawwar,* Randa H. Swellem, and Laila M. Chabaka

*Natural Products Department, National Research Centre, Dokki, Cairo, Egypt

Abstract

An approach to the title ring system starting with the available cinnamoyloximinoacetonitrile (1) is proposed. It involves its reaction with various nucleophiles and subsequent addition of the resulting pyrrole derivatives (3,4) to 2-substituted cinnamonitriles (5), in a Micheal type reaction, thus affording the pyrano[2,3-c]pyrroles (6).