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Paper | Regular issue | Vol 38, No. 4, 1994, pp.803-809
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6620
A Convenient Synthesis of 5-Trifluoromethyl-3-thiazolines and 5-Trifluoromethyl-2,3,4,5-tetrahydro-1,2,4-triazines

Yasuhiro Kamitori, Masaru Hojo, Ryoichi Masuda,* Toshiya Takahashi, Masaaki Wada, Takehiro Hiyama, and Yoshio Mimura

*Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan

Abstract

5-Trifluoromethyl-3-thiazolines (3) and 5-trifluoromethyl-2,3,4,5-tetrahydro-1,2,4-triazine (5) were conveniently synthesized from 3-(N-tert-butyl-N-methylhydrazono)-1,1,1-trifluoroalkan-2-ones (1) with the use of silica gel as an effective catalyst. 5-Trifluoromethylimidazole (6) was also abtained in good yield from 1.