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Paper | Regular issue | Vol 38, No. 3, 1994, pp.587-593
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6596
One-Pot Synthesis of New 1,3-Imidazolidines Possessing Three Aryl Groups via a 1,3-Dipolar Cycloaddition Reaction

Yoshimitsu Nagao,* Kweon Kim, Yoichi Komaki, Shigeki Sano, Masaru Kihara, and Motoo Shiro

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan


Tri-aryl-substituted imidazolidines (3) were readily synthesized by heating a mixture of arylaldehyde (7), diethyl ketomalonate (8), and benzyl(or substituted benzyl)amine (6) in benzene in the presence of a catalytic amount of p-toluene-sulfonic acid.