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Paper | Regular issue | Vol 38, No. 1, 1994, pp.135-142
Published online, 1st January, 1970
DOI: 10.3987/COM-93-6543
Improved Labelling Methods for C9-2H-Retronecine

Jeannette T. Hovermale, Fraser F. Fleming, James D. White, and A. Morrie Craig*

*College of Veterinary Medicine, Oregon State University, Gilbert Hall 153, Corvallis Oregon 97331, U.S.A.


The necine base retronecine (1a), common to numerous toxic pyrrolizidine alkaloids, has previously been labelled with 3H at C-9 for use in metabolic studies. The current method for labelling retronecine is inefficient, and we report here an improved method of which utilizes the Dess-Martin periodinane reagent. Characterization of the resulting aldehyde (2) is described. The overall yield of C9-2H-retronecine (1b) is 71% (from 1a).